The causes of hospital mortality in methadone associated poisonings: analysis of the data from the Kyiv toxicological center for 2005–2019

Scientific interest in poisoning by synthetic opioids, particular Methadone, is due to a significant increase their number Kyiv over the past 15 years and fatal consequences. The Aim of Research. Is identify causes associated with methadone determine measures prevent them. Materials Methods. A retrospective analysis medical data 1340 patients Methadone who were treated at Toxicology Center period 2005–2019; including 38 fatalities cases. Results. share drug poisonings registered has increased from 15% 42% 30 years. top five drugs psychotropic substances 2019 Benzodiazepines, Barbiturates, Amphetamines, Marijuana. 2005–2014 150 times. main cause use illegal Methadone. There direct relationship between growth hospital mortality appearance combined poisonings: Methadone-Ethanol (r = 0,79); Methadone-Ethanol-Amphetamines 0,69); Methadone-Ethanol-Benzodiazepines 0,61); Methadone-Ethanol-Cocaine 0,43). According results forensic studies died as result poisoning, following identified: toxic hepato-nephropathy – 12 cases (31,57%); long-term soft tissue compression syndrome 10 (26,31%); acute kidney damage 4 (10,52%); aspiration gastric contents 7 (18,42%); apallic (10,52%). effect polymorbidity on been confirmed, which justifies need for personalized approach intensive care. Conclusions. Today Ukraine, most common type severe course, high mortality, requires long complex treatment. Key Words: methadone, mortality.